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The Stressed Heart

Name: The Stressed Heart
Brand: Springer, Berlin
SKU: 01401385
Price: 114.93 EUR
Availability: InStock
Author: Marianne J. Legato
ISBN: 9780898388497

Marianne J. Legato

Língua

Inglês

Livro Livro de capa dura

Código Libristo: 01401385

Editoras Springer, Berlin

The Stressed Heart is truly unique in concept and will provide an eXCItmg adventure to the reader no... Descrição completa

Código Libristo: 01401385

277 b

114.93 €

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The Stressed Heart is truly unique in concept and will provide an eXCItmg adventure to the reader no matter what his or her field of expertise and interest. The title, although quite appropriate, does not adequately indicate the range of topics considered or the rational interrelationships among them. Indeed, perhaps the most important point to be learned from the book is that a serious consideration of the response of the heart to mechanical overload, ischemia, or excessive humoral stimuli must include evaluation of each of the topics in the table of contents. The heart responds to stress through alterations in both structure and function. How these changes are brought about is the subject of the initial chapters. These consider first the normal regulation of gene expression in the heart, the rapid response to mechanical overload that leads to both quantitative and qualitative changes in the contractile proteins, and our current understand ing of the signals that might be elicited by stress and alter gene expression. One chapter emphasizes the fact that, regardless of the nature of the stress, the common denominator is a discrepancy between energy requirements and expenditure. The central role of cellular acidosis in initiating the sequence of responses to stress and the possible roles of peptide regulators of transcription and protein regulators of translation are considered in detail.