Contacto
Como comprar
Entrega
Guia de compras
"Synthese von IMIDs®"
Synthese von den immunmodulatorischen Substanzen Revlimid, Actimid und Thalidomid
Alemão
121 b
Até 30 dias para devoluções
Os clientes também compraram
/
Capa mole
26.48
€
/
Capa mole
6.76
€
/
Capa mole
36.39
€
The purpose of this diploma thesis was the synthesis of three different IMIDs Thalidomid, Revlimid and Actimid. The representation of Thalidomid occurered by three different ways and the conversion of isobenzfuran-1,3-dione and 2,6-dioxopiperidin-3-aminium bromide brought the best yield in DMF and triethylamine. Two other synthesis ways could be carried out which also led to the end product Thalidomid, but in doing so, the yield was lower. Once the open-chained glutamine acid was, in first step, converted with the isobenzfuran-1,3-dione to the glutamine acid derivate and afterwards the ring end carried out by the 2,6-dioxotetrahydro- 2H-pyran derivate and the glutamine derivate. In the third synthesis way both source materials from the first reaction guidance were heated up with formic acid under backflow. Likewise, to synthesis the IMID Revlimid several reaction guidance were carried out. The synthesis way with the highest yield proceeded via the alkylation with following ring end to the Amid with 2,6-dioxopiperidin-3-aminium bromide and methyl 2-(bromomethyl)-3- nitrobenzoate.
Sobre o livro
Alemão
Ofereça este livro hoje
É fácil
1 Adicione ao carrinho e escolha Entregar como presente ao finalizar a compra 2 Receberá um vale 3 O livro chegará ao endereço do destinatárioTambém pode estar interessado em
/
Capa mole
95.44
€
/
Capa mole
32.95
€
Olá! Sou o Libroamiko, o seu conselheiro de livros.
Como posso ajudar?