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Microstructured Interpenetrating Polymer Network Drug Delivery System

Name: Microstructured Interpenetrating Polymer Network Drug Delivery System
Brand: LAP Lambert Academic Publishing
SKU: 06883953
Price: 55.6 EUR
Availability: InStock
Author: Subham Banerjee
ISBN: 9783846524398

Development of Novel Interpenetrating Polymer Network Hydrogel Microspheres For Controlled Release of Diclofenac Sodium

Subham Banerjee

Somasree Ray

Pronobesh Chattopadhyay

Língua

Inglês

Livro Capa mole

Código Libristo: 06883953

Editoras LAP Lambert Academic Publishing, novembro 2010

Novel interpenetrating network (IPN) hydrogel microspheres, consisting of xanthan gum and poly(vinyl... Descrição completa

Código Libristo: 06883953

135 b

55.60 €

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Novel interpenetrating network (IPN) hydrogel microspheres, consisting of xanthan gum and poly(vinyl alcohol) were prepared by water-in-oil emulsion crosslinking method using glutaraldehyde for the controlled release of diclofenac sodium,as a model drug.Various formulations were prepared by changing the ratio of XG:PVA, extent of cross-linking in order to optimize the formulation variables on drug encapsulation efciency, and release rate. Formation of IPN and the chemical stability of DS after preparation of microspheres was confrmed by FTIR, DSC & XRD analysis were done which confrmed molecular dispersion of DS in the IPN. Microspheres formed were spherical with smooth surfaces, as evidenced by SEM & mean particle size measured by laser light scattering technique. Drug encapsulation of up to 82.94% was achieved by UV method. Both equilibrium & dynamic swelling studies and in vitro release studies were performed in pH 1.2 and 7.4. Release data indicated Fickian trend of drug release. In vivo pharmacokinetic data showed prolonged drug release as compared with DS solution. Based on the results it was concluded that these IPN microspheres provided controlled release application of DS

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Nome completo Microstructured Interpenetrating Polymer Network Drug Delivery System

Autor Subham Banerjee, Somasree Ray, Pronobesh Chattopadhyay

Língua

Inglês

Encadernação Livro - Capa mole

Data de emissão 2011

Número de páginas 128

EAN 9783846524398

Código Libristo 06883953

Editoras LAP Lambert Academic Publishing

Peso 209

Dimensões 150 x 220 x 8

Categorias

Medicina & enfermagem > Enfermagem & serviços auxiliares > Farmácia/dispensários

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