Microbiome and Cancer

This book will venture into a new and exciting area of discovery which directly ties our current knowledge of cancer to the discovery of microorganisms associated with these cancers. Recent studies demonstrate that microorganisms are directly linked to ongoing establishment of cancers and that they can also contribute to the initiation as well as persistence of the cancers. The book is intended to cover a broad knowledge of microbiome and its association with human cancers. It is intended to provide important reading for the novice, senior undergraduates in cancer and microbiology, graduate students, junior investigators, residents, fellows and established investigators in the field of cancer and microbiology. We will cover areas related to known broad concepts in microbiology and how they can relate to the ongoing discoveries of the micro-environment and the changes in the metabolic and physiologic states in that micro-environment important for the ongoing nurturing and survival of the poly-microbial content which dictates activities in that micro-environment. We will cover the interactions of microorganisms associated with gastric carcinomas which are important for driving this particular cancer. Additional areas will include oral cancers, prostate cancers, skin cancers, ovarian cancers, breast cancers, nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin's and non-Hodgkin's lymphomas, glioblastoma multiforme, hepatocellular carcinomas, as well as the inflammatory response related to the infectious agents in cancers. The metabolic changes which occurs due to infection and its support for development of cancers, chronic infection and development of diagnostic and therapeutic strategies for detection and control of the infection. The field of microbiome research has exploded over the last 5 years and we are now understanding more and more about the context in which microorganisms can contribute to the onset of cancers in humans. We know that the field of microbiome research demonstrated that the human body has specific biomes for tissues and that changes in these biomes at the specific organs sites can result disease. These changes can result in dramatic differences in metabolic shifts that together with genetic mutations will produce the perfect niche for establishment of the particular infection programmes in that organ site. We are just beginning to understand what are those changes and how they influence the disease state. Overall we hope to bring together the varying degrees to which fluctuations in the microbiome at the major organ sites and how these changes affect the normal processes due to dysregulation leading to proliferation of the associated tissues.