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Kinase Screening and Profiling

Methods and Protocols

Said A. Goueli

Hicham Zegzouti

Língua

Inglês

Livro Capa mole

Código Libristo: 18049989

Editoras Humana Press Inc., agosto 2016

This volume focuses on screening and profiling kinase inhibitors or activators. Chapters in this boo... Descrição completa

Código Libristo: 18049989

219 b

90.31 €

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This volume focuses on screening and profiling kinase inhibitors or activators. Chapters in this book cover several facets of the drug discovery processes starting with target identification, and assay development and screening chemical libraries for hit identification and lead optimization. The profiling portion of Kinase Screening and Profiling: Methods and Protocols discusses several strategies and techniques that are required to minimize off target hits and reduce cellular toxicities that are caused by liability kinases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Timely and authoritative, Kinase Screening and Profiling: Methods and Protocols, will benefit scientists and researchers who are interested in exploring the role of kinases in academic, as well as pharmaceutical research.