Contacto
Como comprar
Entrega
Guia de compras
Formulation of Glibenclamide Solid dispersion
Inglês
125 b
Até 30 dias para devoluções
Os clientes também compraram
/
Capa mole
16.38
€
/
Capa mole
56.56
€
/
Capa mole
17.09
€
In present work attempts have been made to formulate solid dispersion of Glibenclamide, by PEG 6000 and PVP K30. which is used as Antidiabetic agent in case of type II diabetes. Solid dispersion were prepared using polymer with PEG 6000 and PVP K30 in different ratio (1:1, 1:5, 1:10) by physical mixture, co-evaporation and melting method. In-vitro dissolution were carried out by keep in the phosphate buffer (pH 7.2) at interval of 4 hr for solid dispersion of different ratio (i.e. 1:1, 1:5, 1:10) & three different methods and results were good dissolution for solid dispersion by co-evaporation, method (CE 1:10) found to be (97.14%). The compatibility evaluations were performed by FTIR spectroscopy and DSC analysis. Both studies implies that the drug and polymers are compatible with each other. Assay were carried out for finally selected solid dispersion and the result were found to be 99.04% by UV Spectrophotometer. Stability studies were carried out by keeping the solid dispersion (CE 1:10) at room temperature and at a 40o C + 2oC / 75 + 5% RH (stability chambers) for 90 days results showing no change in physical appearance and invitro dissolution profile.
Sobre o livro
Inglês
Ofereça este livro hoje
É fácil
1 Adicione ao carrinho e escolha Entregar como presente ao finalizar a compra 2 Receberá um vale 3 O livro chegará ao endereço do destinatárioTambém pode estar interessado em
/
Capa mole
18.40
€
/
Capa mole
13.04
€
/
Capa mole
7.68
€
/
Capa mole
21.64
€
Olá! Sou o Libroamiko, o seu conselheiro de livros.
Como posso ajudar?