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In the past decade, cancer immunotherapy has revolutionized the treatment of hematological and solid tumors, resulting in the approval of checkpoint inhibitory antibodies, CAR-T cell therapies, and T cells engaging bispecific antibodies. Despite this progress, the lack of response and/or relapse and subsequent resistance to immunotherapy remain major clinical challenges requiring the development of optimized therapeutic agents and novel principles for targeting cancer. For this purpose, the application of state-of-the-art antibody engineering continues to play a key role. This Special Issue covers recent progress and novel concepts in the engineering of antibody-based immunotherapies, including monoclonal antibodies, antibody engineering, bi- and multispecific antibodies, photo-and radioimmunotherapy and CAR-T cell therapy manufacturing.
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