Contacto
Como comprar
Entrega
Guia de compras
Brimonidine base-loaded Solid Lipid Nanoparticles for Ocular Delivery
In-vitro, In-vivo Evaluation
Inglês
114 b
Até 30 dias para devoluções
Os clientes também compraram
/
Capa mole
17.22
€
/
Capa mole
33.43
€
Using glyceryl monostearate or Precirol® ATO 5 as solid lipid in 4% w/w concentration in addition to 0.05% w/w Poloxamer® 188, as an emulsifier were optimum for entrapping the hydrophobic Brimonidine base. The prepared solid lipid nanoparticles formulations showed uniform, nanosized particles below 500 nm, suitable for ophthalmic application, of good entrapment efficiency and accompanied by a sustained Brimonidine base release, compared to both Brimonidine(TM) eye drops and Brimonidine dispersion. Glyceryl monostearate solid lipid nanoparticles formulation showed good corneal permeation and localization of the solid lipid nanoparticles in the anterior ocular chamber, acting as a depot for sustained Brimonidine base release. A significant (P 0.05) lowering in intraocular pressure compared to Brimonidine(TM) eye drops and excellent ocular tolerance were determined. It was concluded that; solid lipid nanoparticles formulation is a promising approach for ocular delivery of Brimonidine base to improve its clinical effect.
Sobre o livro
Inglês
Categorias
Ofereça este livro hoje
É fácil
1 Adicione ao carrinho e escolha Entregar como presente ao finalizar a compra 2 Receberá um vale 3 O livro chegará ao endereço do destinatárioTambém pode estar interessado em
/
Livro de capa dura
46.61
€
Olá! Sou o Libroamiko, o seu conselheiro de livros.
Como posso ajudar?