Vertebrate Carbonic Anhydrases

Vertebrate Carbonic Anhydrases, Volume 59 in The Enzymes series, explores recent advances in the study of carbonic anhydrases (CAs) in vertebrate systems. This volume presents a comprehensive collection of chapters examining the diversity, structure, function, and physiological roles of vertebrate CA isoforms across multiple tissues and cellular compartments. Chapters include discussions on the phylogenetic relationships of vertebrate carbonic anhydrases and detailed examinations of several important isoforms, including carbonic anhydrases I, II, and III, as well as membrane-associated enzymes such as CA IV and XV. Additional contributions explore mitochondrial carbonic anhydrases (CA VA and VB), secreted isoforms such as CA VI, and more.The volume also examines acatalytic carbonic anhydrases and tumor-associated isoforms, providing insights into their structural characteristics and biological significance. A concluding chapter addresses current challenges and opportunities in the development of selective inhibitors and activators targeting vertebrate carbonic anhydrase isoforms, highlighting their potential therapeutic applications. - Provides comprehensive reviews on vertebrate carbonic anhydrase isoforms and their biological roles- Includes contributions from leading experts in enzymology, biochemistry, and molecular biology- Covers structural, functional, and evolutionary aspects of multiple carbonic anhydrase families- Explores mitochondrial, cytosolic, membrane-associated, and secreted carbonic anhydrase isoforms- Discusses emerging opportunities for developing selective carbonic anhydrase inhibitors and activators for therapeutic applications