Osmolytes and Intrinsically Disordered Proteins: From Functional Regulation to Disease Pathogenesis

Osmolytes and Intrinsically Disordered Proteins: From Functional Regulation to Disease Pathogenesis, Volume 112 delves into the fascinating interplay between osmolytes and intrinsically disordered proteins (IDPs), exploring their pivotal roles in cellular function and disease mechanisms. This volume brings together experts to present cutting-edge research on how osmolytes regulate functional behavior of IDPs and ensure cellular stability and adaptability under stress conditions. Specific chapters cover Functional diversity of IDPs and their structural heterogeneity: Protein structure-function continuum, Osmolytes as structure-function regulators of intrinsically disordered casein, Synergism of the effects of osmolytes and crowders on structure and function of IDPs/IDRs: The natural habitat, and more.Additional chapters delve into Osmolyte-IDP Interactions during Desiccation, Modulation of aggregation/fibrillation propensity of IDPs by osmolytes, Osmolytes in modulating the structural and functional integrity of a-synuclein: a study based on Parkinson's disease, Regulation of the structural dynamics, aggregation, and pathogenicity of polyQ-expanded Huntingtin by osmolytes, Aggregation and inhibitory strategies of amyloid fibrillation, and much more. - Offers an in-depth exploration of the relationship between osmolytes and intrinsically disordered proteins (IDPs), spanning from basic functional regulation to roles in the pathogenesis of various disease- Features chapters written by leading researchers and experts in the field- Provides the latest findings on osmolyte-IDP interactions in molecular levels and implications in important biological processes- Elucidates on the fundamental science behind IDPs and osmolytes- It highlights potential therapeutic approaches, making it a valuable resource for both researchers and clinicians aiming to develop new treatments for related diseases